... both sequence and expression information from all available genes across multiple species. We also constrain our multivariate models ... can lead to questions about the evolution of genes. They can be compared with ... of LIM (Clim) proteins recruit LIM domain transcription factors to mediate their ...

... loftier view of the variations in mRNA expression across all genes and all measured conditions. We investigated the properties ... microarrays. We show conservation in overall patterns of gene expression levels of variation changes across three species and show associations with known disease ...

... rather takes advantage of correlations with subset-specific genes across a population. Validation using multiple experimental datasets demonstrates ... is to identify descriptions of biological events involving genes or proteins, such as binding events or post-translational modifications. We propose a ...

... to be due to many low penetrance variants across multiple genes. Despite recent successful associations, follow-up work has ... in mouse liver that are regulated by the binding of the FXR protein. Interestingly, our data contains many genes known to be regulated by FXR and many ...

... to develop the ability to identify and normalize genes across multiple species. This will entail the creation of ... primary structure. Identification of new attributes in the gene or protein itself, such as exons, promoter regions, binding sites, repeats, and so on are considered structure ...

... MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 ...

... DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS. Tree ...

... have failed validation. First, in order to discover genes differentially expressed across ovarian cancer studies regardless of stage, we performed ... the Pfam 5 database and identified significantly mutated genes and domains across 42 tumor types with false discovery rate below ...

... public sequencing centers. ΠDevelop approaches to apply standard gene nomenclature across multiple data resources, supporting and working in conjunction ...