... with moderate risk of bias compared melatonin or placebo for 3 months followed by a 1-month washout and 3 months of either melatonin or placebo. 68 Sleep latency and total sleep were significantly ...

... 69), or 40 mg/day (n = 61) or placebo (n = 60) for 4 weeks with forced dose escalation after a washout period. Eligible participants were aged 6 to 17 ... atomoxetine-slow titrating group, n = 61); or (3) placebo (n = 59) for nine ... screening and washout period. The primary outcome was the investigator-rated ...

... three levodopa groups worsened during the 2-week washout period but did not deteriorate to placebo levels. The group receiving the highest dose of ... and 311 (86%) completed the 2 weeks of washout. The percentage of dropouts per group included: placebo (22%), 150 mg/d (15%), 300 mg/d ( ...

... true in the past; apply blinding and active placebos when appropriate, or uniform control treatments otherwise; employ adequate between-arm washout intervals and consider advancing disease state in crossover ...

... true in the past; apply blinding and "active" placebos when appropriate or uniform control treatments otherwise; and employ adequate between-arm washout intervals, and assess side effects. A major limitation ...

... diet with the addition of purified oats or placebo. In this crossover trial, all participants experienced both diets (with or without the addition of oats) with a 3 month washout period in between trials. 7.3.3.3. ...

... 180 days (6 months) of levodopa but required washout period of 60 days prior to study entry. Brooks DJ, Abbott RJ, Lees AJ et al. A placebo-controlled evaluation of ropinirole, a novel D2 agonist, ...

... industry. 108 , 122 , 128 , 171 Two studies included placebo run-in periods to enrich population compliance 172 or confirm eligibility. 122 One study of metformin had a cross-over design with a 2-week washout in between periods. 158 Eight trials were 6 ...

... more people on fludrocortisone in droxidopa arm than placebo (33% -v- ... that 1 week’s washout should have been sufficient in a crossover trial ...

... levothyroxine without dose titration and 50 were given placebo for 12 weeks. Patients then switched treatment arms without a wash-out period. (The half-life of thyroxine is estimated to be 5 to 9 days.) While the absence of a washout period could introduce bias, it would bias the ...