... plasma cells, and fibroblasts. The inflammatory cells are present in different ... a clonal population. Almost all cases of Hodgkin lymphoma arise from ...

... Plasma cell dyscrasias (PCDs) are a group of clonal disorders characterized by the uninhibited expansion of a monoclonal population of malignant plasma cells. 1 Multiple myeloma (MM) is the most common ...

... exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease. Histopathology 69 (3): 499- ...

... 2005 ]. Rhabdomyosarcoma and neuroblastoma, tumors of early childhood, present in Costello syndrome at ages comparable to the general population. In contrast, transitional cell carcinoma of the bladder, which occurs in older ...

... two-hit” hypothesis,[ 6 , 7 ] in which the clonal origin or first transformed cell of the tumor occurs only after both VHL alleles in a cell are inactivated. The inherited germline pathogenic variant in VHL represents the first "hit", which is present in every cell in the body. The second “ ...

... cells usually express surface immunoglobulin, most bearing a clonal surface immunoglobulin M with either kappa or lambda light chains. A variety of additional B-cell markers (e.g., CD19, CD20, CD22) are usually present, and most childhood Burkitt lymphomas/leukemias express CD10.[ ...

... Feng H, Shuda M, Chang Y, et al.: Clonal integration of a polyomavirus in human Merkel cell ... is more frequently present in North American than Australian Merkel cell carcinoma ...