... All people with 3-methylglutaconyl-CoA hydratase deficiency accumulate large amounts of a substance called 3-methylglutaconic ... Aceruloplasminemia is a disorder in which iron gradually accumulates in the brain and other organs. Iron accumulation ...

... damaged DNA. As a result, DNA damage can accumulate in cells. Such cells may continue to divide ... damaged DNA. As a result, DNA damage can accumulate in cells. If such cells continue to divide ...

... DNA are not repaired properly, genetic damage can accumulate. A buildup of errors in DNA can trigger ... these mutations. It is thought that DNA damage accumulates over time, which can trigger cells to grow ...

... involved. In African iron overload, excess iron typically accumulates primarily in certain immune cells called reticuloendothelial cells. ... in the course of the condition, iron also accumulates in liver cells (hepatocytes). This pattern differs from ...

... in which excessive amounts of the element manganese accumulate in the body (hypermanganesemia). One place manganese builds ... also known as hypermanganesemia with dystonia 1), manganese accumulates in the blood, brain, and liver. Signs and ...

... In affected individuals, harmful amounts of fats (lipids) accumulate in cells and tissues throughout the body, which ... onset form of lysosomal acid lipase deficiency, lipids accumulate throughout the body, particularly in the liver, within ...