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243 results
  1. NLM Digital Collections - Enrichment strategies for clinical trials to support determination of effectiveness of human .... 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, March 2019
    resource.nlm.nih.gov/101760015
    ... The study showed a significant effect on the combined endpoint of CV death plus HF hospitalization, which occurred ...
  2. NLM Digital Collections - Management of stable angina : a national clinical guideline 
    Publication: Edinburgh, Scotland : Scottish Intercollegiate Guidelines Network (SIGN), April 2018
    resource.nlm.nih.gov/101730371
    ... patients, nicorandil was shown to significantly reduce the combined endpoint ++ 1 of coronary heart disease death, non-fatal ... 888) reported a significantly lower occurrence of the combined 1+ endpoint (death from any cause, non-fatal MI or ...
  3. NLM Digital Collections - Uncomplicated urinary tract infections : developing drugs for treatment 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, August 2019
    resource.nlm.nih.gov/101760283
    ... to assess an individual patient’s outcome on the combined responder endpoint. 3. A third trial (Gágyor et al. 2015) ...
  4. NLM Digital Collections - Management of stable angina : a national clinical guideline 
    Publication: Edinburgh, Scotland : SIGN, 2007
    resource.nlm.nih.gov/101300496
    ... nicorandil was shown to significantly 1++ reduce the combined endpoint of CHD death, non-fatal myocardial infarction, or ... significantly improves performance on a range of clinical endpoints. ... effective in reducing combined cardiac events. One of these composite endpoints was ...
  5. NLM Digital Collections - Antithrombotics : indications and management : a national clinical guideline 
    Publication: Edinburgh, Scotland : Scottish Intercollegiate Guidelines Network (SIGN), August 2012
    resource.nlm.nih.gov/101609426
    ... more effective than aspirin alone in reducing the combined endpoint of ischaemic stroke, myocardial infarction or vascular death ( ...
  6. NLM Digital Collections - Siponimod for the treatment of secondary progressive multiple sclerosis : effectiveness and ... 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, June 20, 2019
    resource.nlm.nih.gov/9918401086506676
    ... RiskPlacebo – RiskIntervention), ˠ: RR for 160µg and 250µg combined, ¤: the primary endpoint was a multi-component CDP. Results are reported ...
  7. NLM Digital Collections - Patient-focused drug development : collecting comprehensive and representative input : ... 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, June 2020
    resource.nlm.nih.gov/9918230998606676
    ... multiple assessments within an individual are to be combined. (Source: “BEST (Biomarkers, EndpointS, and other Tools) Resource”) Fit-for-Purpose: A ...
  8. NLM Digital Collections - Amyotrophic lateral sclerosis : developing drugs for treatment 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, September 2019
    resource.nlm.nih.gov/101760442
    ... drug effect on survival should be a secondary endpoint. The independent assessment of survival should be combined with an evaluation of the need for full- ...
  9. NLM Digital Collections - Physical Activity and Health: A Report of the Surgeon General 
    Publication: National Center for Chronic Disease Prevention and Health Promotion (U.S.). Office on Smoking and Health, 1996
    resource.nlm.nih.gov/101584932X106
    ... risk of developing colon cancer alone. Studies that combined colon and rectal cancers as a single endpoint—colorectal cancer—are only briefly reviewed here because ...
  10. NLM Digital Collections - Physical Activity and Health: A Report of the Surgeon General (pages 101-125) 
    Publication: National Center for Chronic Disease Prevention and Health Promotion (U.S.). Office on Smoking and Health, 1996
    resource.nlm.nih.gov/101584932X112
    ... risk of developing colon cancer alone. Studies that combined colon and rectal cancers as a single endpoint—colorectal cancer—are only briefly reviewed here because ...
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