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736 results
  1. NLM Digital Collections - Proton beam therapy : final evidence report 
    Publication: [Boston, MA] : Institute for Clinical and Economic Review, [2014]
    resource.nlm.nih.gov/101636381
    ... DCH, Grade I: 43% therapeutic Study Objective Overall cohort • Dose: 16-30 Gy, of PBT vs. photon modality ...
  2. NLM Digital Collections - Abuse-deterrent formulations of opioids : effectiveness and value : final evidence report 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, August 8, 2017
    resource.nlm.nih.gov/101723920
    ... to 60mg and 90mg in up to two cohorts. Dose determination based on drug liking bipolar VAS. Drug ... years; enrolled Opioid dispensing rate, mg morphine equivalent dose per JAMA 2015 72 ... using an open cohort 3) other long acting used Optum data which ...
  3. NLM Digital Collections - Spinraza and Zolgensma for spinal muscular atrophy : effectiveness and value : final evidence ... 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, May 24, 2019
    resource.nlm.nih.gov/9918402188606676
    ... Zolgensma. This Executive Summary focuses on the high-dose cohort only; results from the low-dose cohort are described in Section 3. We did not ... results from the 12 infants in the high- dose cohort. Baseline Characteristics of Key Trials Key baseline characteristics ...
  4. NLM Digital Collections - Valoctocogene roxaparvovec and emicizumab for hemophilia A without inhibitors : effectiveness ... 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, November 20, 2020
    resource.nlm.nih.gov/9918401086706676
    ... IU/dl or greater.14 In the higher dose cohort, the mean annualized bleeding rate (ABR) for treated ... emotional impact, and treatment concerns. In the higher dose cohort, a steady improvement was seen in the Haemo- ...
  5. NLM Digital Collections - Human gene therapy for rare diseases 
    Publication: Silver Spring, MD : Center for Biologics Evaluation and Research, January 2020
    resource.nlm.nih.gov/101767660
    ... initial group of subjects, followed by staggering between dose cohorts. This approach limits the number of subjects who ... optimal dosing interval between consecutively enrolled subjects and dose cohorts should be discussed with OTAT prior to beginning ...
  6. NLM Digital Collections - The Health Consequences of Involuntary Smoking: A Report of the Surgeon General 
    Publication: United States. Office on Smoking and Health, 1986
    resource.nlm.nih.gov/101584932X679
    ... 1976b) subse- quently reported that, in this same cohort, a dose-response relation- ship with parental smoking persisted for ... vs. whole sidestream smoke, 236-238 lung cancer dose-response relation- ship, ... Cancer Society Cohort Study, 76-77 lung cancer risk assessment, impor- ...
  7. NLM Digital Collections - The Health Consequences of Involuntary Smoking: A Report of the Surgeon General (pages 26-50) 
    Publication: United States. Office on Smoking and Health, 1986
    resource.nlm.nih.gov/101584932X682
    ... 1976b) subse- quently reported that, in this same cohort, a dose-response relation- ship with parental smoking persisted for ...
  8. NLM Digital Collections - Elagolix for treating endometriosis : final evidence report 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, August 3, 2018
    resource.nlm.nih.gov/101745008
    ... was 51-52% in the 150 mg daily dose cohort and 76-78% in the 200 mg twice daily dose cohort.26 Nonmenstrual pelvic pain response was 66- 68% in the 150 mg daily dose and 67-69% in the 200 mg twice ...
  9. NLM Digital Collections - Mepolizumab (Nucala??, GlaxoSmithKline plc.) for the treatment of severe asthma with ... 
    Publication: [Boston, MA] : Institute for Clinical and Economic Review, March 14, 2016
    resource.nlm.nih.gov/101678996
    ... the mepolizumab exacerbation trial.14 Table 3. Model Cohort Characteristics High-Dose ICS + Additional Controller(s) Value Primary Source Uncontrolled and ...
  10. NLM Digital Collections - The Health Consequences of Smoking: Cancer and Chronic Lung Disease in the Workplace: A ... 
    Publication: United States. Office on Smoking and Health, 1985
    resource.nlm.nih.gov/101584932X452
    ... 1979b; US DHHS 1984). In the major prospective cohort studies, dose-response relationships between amount smoked and age-specific ... than their younger counterparts, and these same older cohorts probably also ... dose-re- sponse relationships between cumulative asbestos exposure and ...
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