... debate about the suitability of PFS to evaluate clinical benefit. Some clinical experts acknowledge that PFS may be ... the high incremental cost relative to the small clinical benefit observed. Table ES8. Threshold Analysis Results for Niraparib ...

... as having 1 or more comorbid psychiatric condition. Clinical Benefits Valbenazine: Published evidence from two trials showed statistically ... million. In summary, our analyses suggest that the clinical benefits associated with the VMAT2 inhibitors will lead to ...

... and so are described in descriptive fashion only. Clinical Benefits All TIMs produced statistically- and clinically-superior improvements ... the long-term effects of prolonged immunomodulation – both clinical benefits and potential harms -- are not well- understood for ...

... 4,560.16 CardioMEMS Comparative Clinical Effectiveness Results Clinical Benefits The literature search for CardioMEMS identified 23 potentially ... indicate that CardioMEMS has the potential to provide clinical benefit over standard approaches to CHF management. The primary ...

... effectiveness of each intervention vs. alternatives (considering both clinical benefits and harm) 2. Any additional “non-clinical” benefits (e.g., reduced caregiver burden) 3. Contextual considerations ( ...

... Although recent trials have provided some evidence of clinical benefit, these have suffered from methodological concerns and use ... insufficient to determine whether continuous monitoring provides added clinical benefit for these patients. ©Institute for Clinical & Economic Review, ...

... eligible for treatment with a medication. The relative clinical benefit of a drug can vary widely between different ... subpopulations within the same indication. However, despite different clinical benefit across indications, the reimbursement system in the United ...

... change in ALP as a surrogate measure of clinical benefit. Other liver biomarkers, including, aspartate aminotransferase (AST), alanine ... of PBC Return to Table of Contents Results Clinical Benefits In all of these randomized controlled trials there ...

... in published, unpublished, or abstract form, concerning key clinical benefits and surrogate outcomes of clinical benefit as well as potential harms and drug-related ...

... at least the prior six months.13 Results Clinical Benefits The average annual rate of significant exacerbations in ... oral corticosteroid use. This is not of immediate clinical benefit but may reduce the long-term harms of ...