... metastatic; we will ask whether such tumors are associated with activation of genes that have been implicated in tumor progression, including expression of matrix metalloproteases in stromal cells (such as stromolysin -3 [z]) and angiogenic factors. “a Harold E. Varmus, M.D. Use of ...

... that is, the active inhibition of cer- tain genes, an inhibition that also ... of the stable activation of the con- trolling chromosome was the central ...

... transgenic mice. Transgenic studies, in particular, will uncover factors controlling gene activation in the embryonic period, specifically in the photoreceptor ...

... Transgenic studies, in particular, have helped to uncover factors controlling gene activation in the embryonic period, specifically in the photoreceptor ...

... Transgenic Studies. Transgenic studies can help to uncover factors contiolling gene activation in the embryonic period, specifically in retinal photoreceptor ...

... properties and the role of immediate early transcription factors in the activation of delayed early genes (see below). For completeness, | mention that in 1991-' ...

... and total hemisphere Follow-up: 3 yrs cortical activation after gene therapy was associated with improved clinical outcomes of white red and ...

... While it seems to be accelerated by HIV-associated growth factors (the tat gene may upregulate interteukin-6 - IL-6 -- and transforming ...

... sites may play a role in down- regulating gene transcription after initial growth factor-in- duced activation. Further experiments should clarify the role Novel Zinc- ...

... al. 1997, Meyers et al. 1996). Collectively, these genes are associated with cell reg- ulation, either through mediating growth factor effects or by serving as transcription factors (Cohen ...