- NLM Digital Collections - KRAS Mutations and Primary Resistance of Lung Adencarcinomas to Gefitnib or ErlotinibPublication: Public Library of Science, January 2005... Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the downstream GTPase, KRAS, and mutations in ... Some 15%-30% of lung adenocarci- nomas contain activating mutations in the RAS family member KRAS. These mutations ...
- NLM Digital Collections - Management of lung cancer : a national clinical guidelinePublication: Edinburgh, Scotland : Scottish Intercollegiate Guidelines Network (SIGN), February 2014... cell lung cancer with epidermal growth factor receptor activating mutations (January 2012). yy E rlotinib is accepted for ...
- NLM Digital Collections - Enrichment strategies for clinical trials to support determination of effectiveness of human ....Publication: Silver Spring, MD : Center for Drug Evaluation and Research, March 2019... 40% to 60% of all melanomas carry this activating mutation. In a study of 49 patients with melanoma, ...
- NLM Digital Collections - Annual report - National Eye Institute (1994)Publication: [Bethesda, Md.] : National Eye Institute... the lens is overexpression of these genes and negative dominant mutations using retroviral vectors. We have used the avian ... gener- ate mice with heterozygous and homozygous knockout mutations. ... flanked by the negative selectable marker. HSV tk. Use of these positive ...
- NLM Digital Collections - Annual report - National Eye Institute (1992)Publication: [Bethesda, Md.] : National Eye Institute... endoge- nous genes. Preliminary results indicate that a negative dominant mutation of c-jun has a positive effect on ...
- NLM Digital Collections - Severely debilitating or life-threatening hematologic disorders : nonclinical development of ....Publication: Silver Spring, MD : Center for Drug Evaluation and Research, March 2019... testing is generally not warranted. When the bacterial mutation assay is negative, but an in vitro chromosome damage test result ( ...
- NLM Digital Collections - Tubercle bacillus infection and tuberculosis in man and animals : processes of infection and ....Publication: Baltimore : Williams & Wilkins, 1923... cuti-reaction. Of the 12 whose milk was activating, 9 gave a positive tuberculin reaction and 3 a negative reaction. Of the 12 whose milk was non-activating for venom, only one gave a positive cuti- ...
- ... from epidemiologi cal data on human blaod Tynphacytes. - Negative results were reported in a fruit fly point mutation’ study. D.. Toxicology “The oral LD50 of zineb ...
- NLM Digital Collections - Excerpt from UCSF School of Medicine's Department of Biochemistry and Biophysics' 1982-1983 ...Publication: University of California, San Francisco. School of Medicine, [1983]... the assumption that MAV induces renal tumors by activating cellular genes, Dave Westaway has sought the target for insertion mutation. However, none of the cellular homologues of retroviral ...
- NLM Digital Collections - Lecture notes for "Gene Structure and Function"Publication: Produced: 17 May 1990... proteins with the DNA can have either a negative or a positive effect on transcription. Accordingly, the proteins are called transcriptional repressor or activating factors, respectively. To appreciate such regulatory mechanisms it ...
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