... Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the downstream GTPase, KRAS, and mutations in ... Some 15%-30% of lung adenocarci- nomas contain activating mutations in the RAS family member KRAS. These mutations ...

... 40% to 60% of all melanomas carry this activating mutation. In a study of 49 patients with melanoma, ...

... can start anywhere along the gastrointestinal tract. The activating mutations in PDGFRA have been linked to the development ...

... cell lung cancer with epidermal growth factor receptor activating mutations (January 2012). yy E rlotinib is accepted for ...

... Recombinant proviruses Recombinant proviruses were not observed INSERTION MUTATIONS (ACTIVATING OR INACTIVATING) X INTRODUCTION INTO NO Qs FR ...

... be thought to have undergone a variety of "activating" events: transduction to become a viral oncogene, point mutation to produce a gene that transforms cultured cells; ...

... the assumption that MAV induces renal tumors by activating cellular genes, Dave Westaway has sought the target for insertion mutation. However, none of the cellular homologues of retroviral ...

... Borrelia. Although phase variations look at first like mutations, they con- sist of the microbe activating genetic informa- tion that had been silenced during ...

... of sRNA or the specificity of amino acid activating enzymes might occur and might result in a series of phylogenetically related codes rather than one code universal to all species. From an evolutionary point of view, a mutation resulting in a changed code wherein one amino ...

... does not activate the enhancerless SV40 promoter. Point mutations indicated that bases at positions -108 and -109 are essential for the activating properties of the distal domain in explanted chicken ...