- NLM Digital Collections - Hematologic malignancies : regulatory considerations for use of minimal residual disease in ...Publication: Silver Spring, MD : Center for Drug Evaluation and Research, January 2020... transcription polymerase chain reaction (RT-qPCR) of specific gene fusions, and allele- 290 specific oligonucleotide polymerase chain reaction ( ... chronic myeloid 528 leukemia (CML) from targeting the BCR-ABL1 oncoprotein. The detection and monitoring of 529 MRD ...
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