- NLM Digital Collections - Human gene therapy for hemophiliaPublication: Silver Spring, MD : Center for Biologics Evaluation and Research, January 2020... For GT products for hemophilia that express a variant protein with specific activity that deviates from normal, consider developing dedicated activity and antigen assays for the variant protein. Calibrate the factor activity and antigen assay standards ...
- NLM Digital Collections - Report from Cold Spring Harbor, 1979: Viral Oncogenes (and Other Items)Publication: Produced: [1979]... previously appreciated. It appears to be a polymorphic protein, variant from species to species, barely detectable (if at all) in normal ac cells (except for undifferentiated EC cells), induced by ... t what is proabaly the a same protein in a host of m neoplastic cells by ...
- NLM Digital Collections - Morphologic Variation in Pneumococcus: I. An Analysis of the Bases for Morphologic Variation ....Publication: Rockefeller University. Press, 1 July 1953... C car- bohydrate and a type-specific M protein. The capsulated variants differ from non-capsulated variants, however, by virtue ... Structure of Morphologic Variants of Pneumococcus Antigen Morphologic variant | C poly. M protein] SSS saccharide Non-filamentous capsulated + + + IID39S (fl— SVIIIs7) ...
- NLM Digital Collections - Bacterial Transformation ReactionsPublication: American Society for Microbiology, March 1952... of different capsular types associated with the same protein. When an unencapsulated R variant of pneumococcus is grown in the presence of homologous anti-M protein serum or when an ER variant is selected from it by appropriate cultural techniques, ...
- NLM Digital Collections - Program in Molecular Neurobiology ProposalPublication: Produced: 30 August 1962... glutamine amide groups to give a series of variant proteins differing in ionic charge distribution from the basic ...
- NLM Digital Collections - Acquisition of M Protein by Pneumococci through Transformation ReactionsPublication: Rockefeller University. Press, 1 April 1949... alternative method for obtaining cells deficient in M protein was sought by growing rough variants of pneumococcus II-R36NC according to the method ... serum broth. A Griffith rough variant containing M1 protein was obtained ... eight transfers. This variant was then exposed in viiro to a transforming ...
- NLM Digital Collections - Mixing, diluting, or repackaging biological products outside the scope of an approved ...Publication: Silver Spring, MD : Center for Drug Evaluation and Research, January 2018... Assay). Product-related impurities including, at a minimum, protein aggregation, and variants in the size and charge of the protein49 ...
- NLM Digital Collections - Review of intramural research (1966)Publication: [Bethesda, Md.] : U.S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health... in nature. Biochemical Investigations 1. Pregnancy-associated plasma proteins. 2. Electrophoretic variants of leucocyte al- kaline phosphatase. 3. Inhibition studies ...
- NLM Digital Collections - Emergency Use Authorization for vaccines to prevent COVID-19Publication: Silver Spring, MD : Center for Biologics Evaluation and Research, May 25, 2021... improve virus fitness for transmission. SARS-CoV-2 variants that include mutations in the S protein were identified within a few months after the ... research focus. The emergence of SARS-CoV-2 variants with multiple mutations in the S protein in the United Kingdom (B.1.1.7 ...
- NLM Digital Collections - German military neuropsychiatry and neurosurgeryPublication: [London?] : Combined Intelligence Objectives Sub-Committee, [1945]... performed in all such cases, since the organic variant frequently showed increased protein in the spinal fluid and a lesser increase ...
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