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  1. ... metastatic; we will ask whether such tumors are associated with activation of genes that have been implicated in tumor progression, including expression of matrix metalloproteases in stromal cells (such as stromolysin -3 [z]) and angiogenic factors. “a Harold E. Varmus, M.D. Use of ...
  2. NLM Digital Collections - Molecular Genetics 
    Publication: Encyclopedia Britannica, 1971
    ... that is, the active inhibition of cer- tain genes, an inhibition that also ... of the stable activation of the con- trolling chromosome was the central ...
  3. NLM Digital Collections - Annual report - National Eye Institute (1992) 
    Publication: [Bethesda, Md.] : National Eye Institute
    ... transgenic mice. Transgenic studies, in particular, will uncover factors controlling gene activation in the embryonic period, specifically in the photoreceptor ...
  4. NLM Digital Collections - Annual report - National Eye Institute (1993) 
    Publication: [Bethesda, Md.] : National Eye Institute
    ... Transgenic studies, in particular, have helped to uncover factors controlling gene activation in the embryonic period, specifically in the photoreceptor ...
  5. NLM Digital Collections - Annual report - National Eye Institute (1994) 
    Publication: [Bethesda, Md.] : National Eye Institute
    ... Transgenic Studies. Transgenic studies can help to uncover factors contiolling gene activation in the embryonic period, specifically in retinal photoreceptor ...
  6. NLM Digital Collections - PCORI Health Care Horizon Scanning System : horizon scanning status report : December 2019 
    Publication: Washington, DC : Patient-Centered Outcomes Research Institute, December 2019
    ... have hemophilia also calls valrox) is an adeno-associated virus vector gene Factor VIII replacement Quality of life License Application planned ...
  7. ... properties and the role of immediate early transcription factors in the activation of delayed early genes (see below). For completeness, | mention that in 1991-' ...
  8. NLM Digital Collections - Voretigene neparvovec for biallelic RPE65-mediated retinal disease : effectiveness and value :... 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, February 14, 2018
    ... and total hemisphere Follow-up: 3 yrs cortical activation after gene therapy was associated with improved clinical outcomes of white red and ...
  9. NLM Digital Collections - PCORI Health Care Horizon Scanning System : horizon scanning status report : September 2019 
    Publication: Washington, DC : Patient-Centered Outcomes Research Institute, September 2019
    ... Men aged 18 years or older AMT-061 gene therapy consists of adeno-associated viral Factor IX replacement Bleeding episodes FDA designation(s): who have ...
  10. ... While it seems to be accelerated by HIV-associated growth factors (the tat gene may upregulate interteukin-6 - IL-6 -- and transforming ...
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