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Abnormal lymphocyte proliferation
- ... of PI3K-delta signaling can also stimulate the abnormal proliferation of lymphocytes, and accumulation of these cells can lead to ...
- ... not inherited and are found only in the abnormal lymphocytes. (Such mutations are known as somatic mutations.) The mutations involved in LGL are classified as "gain-of-function," leading to an overactive ... acute-phase ...
- ... from B cells known as plasma cells. These abnormal cells with both lymphocyte and plasma characteristics are known as lymphoplasmacytic cells. ... signaling through these overactive proteins allows survival and proliferation of abnormal cells that should undergo apoptosis, which likely contributes ...
- ... numbers of T cells, B cells, and other lymphocytes called macrophages. This proliferation of immune cells often causes a life-threatening ...
- ... NF-κB signaling. Overactive NF-κB promotes the proliferation of B cells, which can lead to B-cell lymphoma. These abnormal cells, however, cannot respond to infections. T cells ...
- Laboratory Tests (Immune Deficiency Foundation)Immune System and Disorders/Diagnosis and Tests ... Immune System and Disorders ... Immune Deficiency Foundation ... Laboratory tests that measure different parts of ...