... early 20s, sensory impairment, sudomotor dysfunction (loss of sweating), and dementia usually beginning in the mid-40s. ... late 40s. Autonomic neuropathy, manifest as loss of sweating (sudomotor abnormalities). Significant symptoms of autonomic neuropathy usually ...

... gain, reduced muscle mass, and variable cold intolerance, sweating, elevated heart rate, and irritability) and pathognomonic thyroid ... gain Reduced muscle mass Variably present: cold intolerance, sweating, elevated heart rate, irritability Craniofacial. Common facial findings ...

... relatively large fleshy hands, dysplastic toenails, and decreased perspiration that results in a tendency to overheat. Normal ... extended periods in the sun due to reduced perspiration and tendency to overheat easily; exposure to excessive ...

... to-complete alopecia, nail dystrophy, and palmoplantar hyperkeratosis. Sweating is preserved and there are usually no dental ... joints), palmoplantar hyperkeratosis, and clubbing of the fingers. Sweat glands, sebaceous glands, and teeth are normal. The ...

... acroparesthesia), the appearance of vascular cutaneous lesions (angiokeratomas), sweating abnormalities (anhidrosis, hypohidrosis, and rarely hyperhidrosis), characteristic corneal ...