... overactivates WHSC1, which appears to promote the uncontrolled growth and division of cancer cells. National Human Genome Research Institute: Chromosome Abnormalities PubMed Bergemann AD, Cole F, Hirschhorn K. The ...

... 18 often have slow growth before birth (intrauterine growth retardation) and a low birth weight. Affected individuals may have heart defects and abnormalities of other organs that develop before birth. Other ...

... and abnormally shaped, and they may have skin growths in front of them called preauricular tags. There may also be abnormalities of the ear canal, the tiny bones in ...

... early development. Impaired cell migration disrupts the normal growth and development of several tissues and organs, which leads to the various abnormalities that occur in this disorder. Researchers suggest that ...

... pigmentation) are also possible.The most common eye abnormality in ECCL is a noncancerous growth called a choristoma. These growths can be present ... called a glioma. The brain and spinal cord abnormalities associated with ECCL can ... kinds of growths may also occur in people with ECCL, including ...

... to cause spondyloperipheral dysplasia. This disorder of bone growth is characterized by disproportionate short stature, brachydactyly, platyspondyly, and other skeletal abnormalities. The COL2A1 gene variants that cause spondyloperipheral dysplasia ...

... enough normal microfibrils to store TGF-β, the growth factor is abnormally active. These effects likely contribute to the physical abnormalities that occur in acromicric dysplasia, but the mechanisms ...

... to moderate short stature during childhood, but their growth usually catches up with that of their peers during puberty. Hand abnormalities are common in this syndrome and include short ...

... enough normal microfibrils to store TGF-β, the growth factor is abnormally active. These effects likely contribute to the physical abnormalities that occur in acromicric dysplasia, but the mechanisms ...