... Search term GeneReviews Advanced Search Help < Prev Next > Tyrosine Hydroxylase Deficiency Yoshiaki Furukawa , MD, PhD and Stephen ... Estimated reading time: 30 minutes Summary Clinical characteristics. Tyrosine hydroxylase (TH) deficiency is associated with a broad ...

... that are not sensitive to 131I. Targeted therapy Tyrosine kinase inhibitors Sorafenib Sorafenib is an orally active ... new approaches to treating this disease. Targeted therapy Tyrosine kinase inhibitors Sorafenib Sorafenib is an orally active, ...

... rate was 89.3% at 24 months.[ 29 ] Tyrosine kinase inhibitors Targeted therapy has been used to ... following: Gemcitabine and docetaxel.[ 7 ] Trabectedin.[ 8 - 10 ] Tyrosine Kinase Inhibitors Evidence (tyrosine kinase inhibitors): Pazopanib. Pazopanib ...

... therapeutic intracellular concentrations in GIST cells.[ 1 , 13 ] Tyrosine Kinase Inhibitor (TKI) Therapy TKIs work by inhibiting ... in: Treatment of Resectable Primary GISTs Advanced GIST Tyrosine Kinase Inhibitors Imatinib Demetri GD, von Mehren M, ...

... 96).[ 41 , 44 ][ Level of evidence B1 ] EGFR tyrosine kinase inhibitors (TKIs) with or without chemotherapy (for ... on or after platinum-based therapy. ALK-directed tyrosine kinase inhibitors (TKIs) ALK-directed TKIs after first- ...

... online . Last accessed August 23, 2024. Historical (Pre–Tyrosine Kinase Inhibitor) Therapy for Childhood CML Before the tyrosine kinase inhibitor (TKI) era, allogeneic hematopoietic stem cell ...

... transplant; TKIs = tyrosine kinase inhibitors. Targeted Therapy With Tyrosine Kinase Inhibitors (TKIs) The optimal front-line treatment ... CML involves specific inhibitors of the BCR::ABL tyrosine kinase. Although imatinib mesylate has been extensively studied ...