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  1. Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK83261
    ... phase I-II randomized clinical studies have examined isoflavones and soy product for bioavailability , safety, and effectiveness in prostate cancer prevention or treatment.[ ...
  2. Effects of Soy on Health Outcomes: Summary - AHRQ Evidence Report Summaries - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK11870
    ... on the health effects of soy and its isoflavones on the following: menopausal symptoms, bone health, cancers, cardiovascular diseases, kidney diseases and cognitive function, as well as safety issues and drug interactions. In addition, this report ...
  3. Hot Flashes and Night Sweats (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK65745
    ... some confusion about the mechanisms of action and safety of these plant-based estrogens. Isoflavones have properties that can cause estrogen-like effects ...
  4. Hormone Interventions - Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical ... 
    https://www.ncbi.nlm.nih.gov/books/NBK442413
    ... JH, et al. A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age Ageing. ...
  5. Menopause: diagnosis and management - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK552590
    ... to women that there is some evidence that isoflavones or black cohosh may relieve vasomotor symptoms. However, explain that: multiple preparations are available and their safety is uncertain different preparations may vary interactions with ...
  6. References for Appendixes - Management of Insomnia Disorder - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK343491
    ... H, Brandao LC, D'Almeida V, et al. Isoflavones decrease insomnia in postmenopause. Menopause. 2011 Feb; 18 (2):178–84. [ PubMed : 20729765 ] 128. Zick SM, Wright BD, Sen A, et al. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary ...
  7. Discussion - Menopausal Symptoms: Comparative Effectiveness of Therapies - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK285467
    ... large trials examining vitamin E, small trials of isoflavones, and ... neither were safety signals apparent. However, given the large numbers of ...
  8. Excluded Studies - Prostate-Specific Antigen-Based Screening for Prostate Cancer - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK82306
    ... IU, Forman JD, Sarkar FH, et al. Soy isoflavones in conjunction with radiation therapy in patients with ... H, Tsukamoto T, et al. Efficacy and safety of dutasteride on prostate cancer risk reduction in ...
  9. List of Excluded Studies - Menopausal Symptoms: Comparative Effectiveness of Therapies - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK285458
    ... W. W., Kim H. The role of soy isoflavones in menopausal health: Report of the North American ... T., Bao W., Ninan P. T. Efficacy and safety of desvenlafaxine 50 mg/d in a randomized, ...
  10. NLM Digital Collections - Fezolinetant for moderate to severe vasomotor symptoms associated with menopause : ... 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, January 23, 2023
    resource.nlm.nih.gov/9918697386406676
    ... not be offered as first line treatment. 3. Isoflavones and black cohosh have some evidence but there is substantial uncertainty due to the different preparations on the market, unknown safety, and potential drug-drug interactions. ©Institute for Clinical ...
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