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Increased cerebral lipofuscin
- ... involves the buildup of an abnormal material called lipofuscin in the brain. NCL is thought to be caused by problems ... Symptoms of NCL include: Abnormally increased muscle tone or spasm ... Movement disorder Loss of speech Seizures Unsteady walk
- ... have decreased sharpness of vision (visual acuity) and increased sensitivity to light (photophobia). There are two types ...
- ... up in tissue. A fatty brown pigment called lipofuscin collects in many tissues, as do other fatty ... Medicines Overactive thyroid gland Significant life changes Sudden increased physical demands on the body, such as a ...
- ... into electrical signals that are transmitted to the brain. The ABCA4 protein removes one of ... (acuity), an increased sensitivity to light (photophobia), and impaired color vision. ...
- ... the heart include deposits of the "aging pigment," lipofuscin . The heart muscle cells degenerate slightly. The valves ... because there is less blood flow to the brain. The capillary walls thicken slightly. This may cause ...