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Results 1 - 9 of 9 for GANGLIOSIDE GM2
  1. GM2A gene 
    ... provides instructions for making a protein called the ganglioside GM2 activator. This protein is necessary for the normal ... beta-hexosaminidase A. Beta-hexosaminidase A and the ganglioside GM2 activator protein work together in lysosomes, which are ...
    https://medlineplus.gov/genetics/gene/gm2a - Genetics
  2. GM2 activator deficiency 
    ... provides instructions for making a protein called the ganglioside GM2 activator. This protein is required for the normal ... beta-hexosaminidase A. Beta-hexosaminidase A and the ganglioside GM2 activator protein work together in lysosomes, which are ...
    https://medlineplus.gov/genetics/condition/gm2-activator-deficiency - Genetics
  3. Tay-Sachs disease 
    ... tissue called gangliosides. Without this protein, gangliosides, particularly ganglioside GM2, build up in cells, often nerve cells in ...
    https://medlineplus.gov/ency/article/001417.htm - Medical Encyclopedia
  4. Tay-Sachs disease 
    ... A helps break down a fatty substance called GM2 ganglioside found in cell membranes. HEXA gene variants affect ... the beta-hexosaminidase A enzyme to break down GM2 ganglioside. As a result, GM2 ganglioside accumulates to toxic ...
    https://medlineplus.gov/genetics/condition/tay-sachs-disease - Genetics
  5. Sandhoff disease 
    ... A helps break down a fatty substance called GM2 ganglioside.Variants in the HEXB gene disrupt the activity ... these enzymes from breaking down certain molecules, including GM2 ganglioside. As a result, these compounds can accumulate to ...
    https://medlineplus.gov/genetics/condition/sandhoff-disease - Genetics
  6. HEXB gene 
    ... complex that breaks down a fatty substance called GM2 ganglioside. Sandhoff disease is caused by variants (also known ... results in an inability to properly break down GM2 ganglioside and other molecules, which allows these compounds to ...
    https://medlineplus.gov/genetics/gene/hexb - Genetics
  7. HEXA gene 
    ... complex that breaks down a fatty substance called GM2 ganglioside found in cell membranes. More than 210 variants ( ... enzyme activity prevents the enzyme from breaking down GM2 ganglioside. As a result, this substance builds up to ...
    https://medlineplus.gov/genetics/gene/hexa - Genetics
  8. About Tay-Sachs Disease From the National Institutes of Health (National Human Genome Research Institute)  
    Tay-Sachs Disease/Start Here ... Tay-Sachs Disease ... National Human Genome Research Institute ... From the National Institutes of Health ... Tay-Sachs disease is a fatal ...
    https://www.genome.gov/Genetic-Disorders/Tay-Sachs-Disease - External Health Links
  9. GM1 gangliosidosis 
    ... down several molecules, including a substance called GM1 ganglioside. GM1 ganglioside is important for normal functioning of neurons in ... are not as effective at breaking down GM1 ganglioside as the normal version of the enzyme. Without ...
    https://medlineplus.gov/genetics/condition/gm1-gangliosidosis - Genetics