- ... full citations Table H-37 Key Question 3i : Cohort study of decreasing opioid doses or of tapering off opioids versus continuation of ... full citations Table H-38 Key Question 3i : Cohort study of decreasing opioid doses or of tapering off opioids versus continuation of ...
- ... high-dose cyclophosphamide cohort than in the low-dose cohort (94% vs. 38%); the response rate was higher ... the MRD cohort than in the morphological disease cohort (93% vs. 50%). Of ... dose of cyclophosphamide conditioning. In an effort to overcome ...
- ... three RCTs 73 , 117 , 131 , and a prospective cohort 185 ): Different doses of aripiprazole are probably of little or no ... synthesis below focuses on the differences between these doses. The cohort study 185 (N = 21) investigated three high doses ( ...
- ... elevated bleeding risk above baseline. In one large cohort study, low-dose ASA significantly increased rates of hospitalization for bleeding ... results stratified by medication use. In the large cohort study that compared low-dose ASA users to propensity-score matched never-users, ...
- ... meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. Neuro Oncol 21 ( ... review of radiation-associated hypothyroidism.[ 20 ] Among seven cohorts (250 patients), the dose associated with a 50% risk (D50) of hypothyroidism ...
- ... limited but reported similar findings (SOE: low). Two cohort studies found higher doses of long-term opioid therapy associated with increased ... of overdose or overdose mortality (SOE: low). One cohort study found higher dose of opioids associated with increased risk of all- ...
- ... these interventions. Table 7-D Spinal anesthesia (Different doses): Cohort studies. Mortality (30-day) . One cohort study 82 ( ... 03, 0.51; p = 0.004). Similarly, one cohort study 82 (n = 291) reported a statistically significant difference ... Bradycardia was reported in two RCTs 61 , ...
- ... both groups and 45–50 in the Stein cohort study. The rFVIIa dose range of 40–200 μg/kg in the ... received just one dose. Patients in the Gelsomino cohort 121 received the lowest doses of rFVIIa in all of the cohort studies, ...
- NLM Digital Collections - Expansion cohorts : use in first-in-human clinical trials to expedite development of oncology ...Publication: Silver Spring, MD : Center for Drug Evaluation and Research, March 2022... avoid medication errors when treatment plans differ by cohort (dose-escalation versus dose-expansion and between individual expansion ...
- ... not reached. RR was similar in the two-dose cohorts, with fewer adverse events at the lower dose, leading to FDA approval of the 200-mg ... infusion administered every 3 weeks) of the trial dose given as 3 mg/kg IV over 30 ... I expansion cohort trial ( NCT02383212 ) that required patients to have at ...
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