... following: Bone marrow and CNS: Bone marrow and CNS involvement at diagnosis usually requires more intensive therapy.[ 19 , ... of 90%.[ 19 , 28 , 32 ] The combination of CNS involvement and bone marrow disease appears to impact outcome ...

... resulting convulsions, anemia, thrombocytopenia, visual impairment, and/or CNS involvement (see Table 1 ). Table 1. Diagnostic Features of ... Absent Absent Visual impairment Frequent Rare Very rare CNS involvement Severe to absent Absent Absent Age of onset ...

... pituitary gland, thyroid, thymus, and central nervous system (CNS). Involvement of every organ except kidney and gonads has ... appear to be at higher risk of LCH CNS involvement and LCH CNS neurodegenerative syndrome. These patients should ...

... Subtypes View in own window Age Subtype Primary CNS Involvement Bone Disease 1 Other Adult Type 1 No ... involving analogs that may be efficacious for primary CNS involvement are ongoing [ Larsen et al 2012 , Marshall et ...

... complication particularly in the later stages of disease. CNS involvement can also contribute to sleep apnea. The voice ... a result of obstructive airway disease and possibly CNS involvement occurs in attenuated MPS I. Gastrointestinal system. Hernias ...

... Therapy For single HSCT for extraocular retinoblastoma with CNS involvement and for metastatic rhabdomyosarcoma. The evidence suggests no ... transplantation of metastatic rhabdomyosarcoma, extraocular retinoblastoma with no CNS involvement, trilateral retinoblastoma, and five types of glial tumor ( ...

... SPG2 manifests as spastic paraparesis with or without CNS involvement and usually normal life span. Intrafamilial variation of ... spasticity and ataxia Spastic paraparesis with or without CNS involvement Spastic urinary bladder Imaging features Magnetic resonance imaging ( ...

... appropriate assessment of development and behavior Evaluation of CNS involvement Blood pressure and serum creatinine concentration Urinalysis, serum ... Oral-Facial-Digital Type I. (OFD1) Collaborative Group. CNS involvement in OFD1 syndrome: a clinical, molecular, and neuroimaging ...

... over 60 years, those with bone marrow or CNS involvement) remains more contentious. Groups of patients with worse ...

... and IgA Establishing the presence or extent of CNS involvement by evaluating the CSF and performing neuroimaging and ...