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  1. NLM Digital Collections - S9 nonclinical evaluation for anticancer pharmaceuticals : questions and answers 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, June 2018
    resource.nlm.nih.gov/101734357
    ... Food and Drug Administration. Antineoplastic Agents -- therapeutic use Clinical Trials as Topic Drug Evaluation, Preclinical Antineoplastic Agents -- toxicity Drug Approval Drug Contamination Research Design Toxicity ...
  2. pdfNLM Technical Bulletin, no.93-104 
    https://www.nlm.nih.gov/.../nlmarchives/techbull/93-104-1977.pdf
    ... file contains detailed descriptions of all phases of clinical trials: Phase I studies which attempt to define an agent's limiting toxicities, time courses, dose-response relationships, etc.; ...
  3. NLM Digital Collections - Chronic hepatitis C virus infection : developing direct-acting antiviral drugs for treatment 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, November 2017
    resource.nlm.nih.gov/101719919
    ... Services. United States. Food and Drug Administration. Antiviral Agents -- therapeutic use Clinical Trials as Topic Drug Evaluation, Preclinical -- standards Drugs, Investigational -- therapeutic use ...
  4. NLM Digital Collections - Return of Elevated Blood Pressure after Withdrawal of Antihypertensive Drugs 
    Publication: American Heart Association, June 1975
    resource.nlm.nih.gov/101584929X125
    In this follow-up to several earlier clinical trials, the Veterans Administration Cooperative Study on Antihypertensive Agents reported on the gradual return of hypertension in a majority of patients that had ceased taking antihypertensive drugs.
  5. Profiles in Science 
    https://profiles.nlm.nih.gov
    ... of the first double-blind, multi-institutional controlled clinical trial of cardiovascular drugs, the Veterans Administration Cooperative Study on Antihypertensive Agents. This landmark study demonstrated that treating high blood ...
  6. About this Collection | Edward D. Freis - Profiles in Science 
    https://profiles.nlm.nih.gov/spotlight/xf
    ... of the first double-blind, multi-institutional controlled clinical trial of cardiovascular drugs, the Veterans Administration Cooperative Study on Antihypertensive Agents. This landmark study demonstrated that treating high blood ...
  7. Annotated Bibliography of Animal Models Literature With Framework Mapping - Mechanistic Evidence in Evidence-Based ... 
    https://www.ncbi.nlm.nih.gov/books/NBK154591
    ... studies appear not to be predictive of human clinical trials. With regard to (3), the authors advocate for preclinical studies that utilize the appropriate agent doses, and pharmacokinetic and pharmacodynamic parameters to take ...
  8. NLM Digital Collections - Comparison of Prazosin with Hydralazine in Patients Receiving Hydrochlorothiazide: A ... 
    Publication: American Heart Association, October 1981
    resource.nlm.nih.gov/101584929X52
    ... in Patients Receiving Hydrochlorothiazide A Randomized, Double-blind Clinical Trial VETERANS ADMINISTRATION COOPERATIVE STUDY GROUP ON ANTIHYPERTENSIVE AGENTS SUMMARY The antihypertensive efficacy and the incidence of ...
  9. NLM Digital Collections - Recurrent herpes labialis : developing drugs for treatment and prevention 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, November 2017
    resource.nlm.nih.gov/101719926
    ... Services. United States. Food and Drug Administration. Antiviral Agents -- therapeutic use Clinical Trials as Topic Drug Evaluation, Preclinical Drugs, Investigational -- therapeutic use Herpes ...
  10. NLM Digital Collections - Complicated intra-abdominal infections : developing drugs for treatment 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, May 2018
    resource.nlm.nih.gov/101734269
    ... United States. Food and Drug Administration. Anti-Bacterial Agents -- therapeutic use Clinical Trials as Topic Drug Evaluation -- standards Drugs, Investigational -- pharmacokinetics Intraabdominal Infections -- ...
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