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165 results
  1. Thyroid Cancer Treatment (Adult) (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK65719
    ... or follicular thyroid cancer. Oral inhibitors targeting specific activating point mutations are under clinical evaluation, as are new immunotherapy ... or follicular thyroid cancer. Oral inhibitors targeting specific activating point mutations are under clinical evaluation, as are new immunotherapy ...
  2. Childhood Astrocytomas Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK65944
    ... 60% to 80% of DNETs, and include FGFR1 activating point mutations, internal tandem duplication of the kinase domain, and activating gene fusions.[ 42 , 67 , 68 ] BRAF mutations are ...
  3. PDGFRA-associated chronic eosinophilic leukemia: MedlinePlus Genetics 
    https://medlineplus.gov/...-associated-chronic-eosinophilic-leukemia
    ... C, Reiter A, Koschmieder S. Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and ...
  4. PDGFRA gene: MedlinePlus Genetics 
    https://medlineplus.gov/genetics/gene/pdgfra
    ... C, Reiter A, Koschmieder S. Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and ...
  5. NLM Digital Collections - Tumor Viruses and Oncogenes 
    Publication: Produced: [1973-1984]
    resource.nlm.nih.gov/101584926X300
    ... be thought to have undergone a variety of "activating" events: transduction to become a viral oncogene, point mutation to produce a gene that transforms cultured cells; ...
  6. NLM Digital Collections - Annual report - National Eye Institute (1988) 
    Publication: [Bethesda, Md.] : National Eye Institute
    resource.nlm.nih.gov/7802080X16
    ... domain does not activate the enhancerless SV40 promoter. Point mutations indicated that bases at positions -108 and -109 are essential for the activating properties of the distal domain in explanted chicken ...
  7. NLM Digital Collections - Characteristics and Composition of RNA Coding Units 
    Publication: National Academy of Sciences (U.S.), April 1962
    resource.nlm.nih.gov/101584910X450
    ... of sRNA or the specificity of amino acid activating enzymes might occur and might result in a series of phylogenetically related codes rather than one code universal to all species. From an evolutionary point of view, a mutation resulting in a changed code wherein one amino ...
  8. NLM Digital Collections - Pesticides, 1977 
    https://resource.nlm.nih.gov/101084435X296
    ... and E. coli detecting either forward or back point (gene) mutations ... activating host and Salmonella typhimurium G46, Serratia marcescens leu” ...
  9. Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK65842
    ... the following: Evidence of WNT pathway activation by activating mutations in the CTNNB1 gene is common.[ 69 - 71 ] ... 30%) than in nonanaplastic cases (11.2%).[ 117 ] Activating mutations at codon 44 (p.P44L) were identified in ...
  10. Familial Hyperinsulinism - GeneReviews® - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK1375
    ... phenotypes in children with hyperinsulinism caused by glucokinase activating mutations. Diabetes. 2009; 58 :1419–27. [ PMC free article : ...
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