... back or ribs Bone lesions Easily broken bones (fractures) Fatigue . Anemia (low level of red blood cells). Fever for no known reason or frequent infections. Easy bruising or bleeding . Trouble breathing . High levels of calcium in the blood (hypercalcemia). It can affect many organs in the body. The symptoms it causes may depend on which organs are affected. Symptoms of multiple sclerosis may include: Numbness, tingling, or pain in the face, arms, and/or legs Vision problems Muscle weakness, ...