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- ... muscle weakness, mostly in the arms and legs. Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It is ... eat, and breathe. There is no cure for ALS, and it gets worse over time. To understand ... Foundation for Medical Education and Research; c1998-2023. Amyotrophic lateral sclerosis: Symptoms and causes; 2023 Apr 25 [cited 2023 ...