... combination of the following: Physical issues, such as: Abnormal facial features. These include small eyes, a thin upper lip, and a smooth skin surface between the nose and upper lip. Small head size. Lower than average height and weight. Poor coordination. Vision and hearing problems. Problems with their heart, kidneys, or bones. Learning challenges, such as: Intellectual disability. Delayed development. Difficulty concentrating. Poor memory. Speech and language delays . Behavioral issues, such as: Hyperactivity Poor social ...