Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Search help
5 results
  1. Hidrotic Ectodermal Dysplasia 2 - GeneReviews® - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK1200
    ... syndrome) is characterized by dystrophy of the nails, alopecia (partial or total), hyperpigmentation of the skin (especially over the joints), palmoplantar hyperkeratosis, and clubbing of the fingers. Sweat glands, sebaceous ...
  2. Nonsyndromic Hearing Loss and Deafness, DFNB1 - GeneReviews® - NCBI Bookshelf 
    https://www.ncbi.nlm.nih.gov/books/NBK1272
    ... birth, erythroderma develops, with spiky and cobblestone-like hyperkeratosis of the entire skin surface appearing by age one year. Severe palmoplantar keratoderma and scarring alopecia occur in some. HID syndrome is considered to ...
  3. GJA1 gene: MedlinePlus Genetics 
    https://medlineplus.gov/genetics/gene/gja1
    ... PubMed Catalog of Genes and Diseases from OMIM PALMOPLANTAR KERATODERMA AND CONGENITAL ALOPECIA 1; PPKCA1 GAP JUNCTION PROTEIN, ALPHA-1; GJA1 SYNDACTYLY, TYPE III; SDTY3 Gene and Variant Databases NCBI Gene ClinVar References Boyden LM, Craiglow BG, Zhou J, Hu R, ...
  4. xmlTopicIndex.xml 
    https://medlineplus.gov/download/TopicIndex.xml
    ... name >PPK-deafness syndrome</other_name><other_name >Palmoplantar hyperkeratosis-deafness syndrome</other_name><other_name >Palmoplantar hyperkeratosis- ...
  5. Clouston syndrome: MedlinePlus Genetics 
    https://medlineplus.gov/genetics/condition/clouston-syndrome
    ... of the hands and soles of the feet (palmoplantar hyperkeratosis); areas of the skin, especially over the joints, ...