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  1. Varicose and other vein problems - self-care 
    https://medlineplus.gov/ency/patientinstructions/000615.htm
    ... you may have: Varicose veins Swelling in your legs Skin changes (stasis dermatitis) or even a skin ulcer (sore) in your lower legs These problems may ...
  2. MedlinePlus Drug Information: Nilotinib 
    https://medlineplus.gov/druginfo/meds/a608002.html
    ... are taking a medication for indigestion, heartburn, or ulcers such as cimetidine, famotidine, nizatidine (Axid®), or ranitidine, ... discomfort, problems walking or speaking, numbness, change in leg skin color, or pain or cold sensation in legsstomach ...