... antimicrobial prophylaxis.[ 3 ] Due to the risk of clonal evolution, treatment with granulocyte colony-stimulating factor (G-CSF) ... with the following: recurrent infections, transfusion dependency, or clonal evolution into a myeloid malignancy.[ 9 - 11 ] Several cases ...

... TAD).[ 7 ] Genomic heterogeneity (in terms of somatic clonal evolution) is common, even among asymptomatic individuals with germline ... 80% of evaluated individuals with RUNX1 -FPD demonstrate clonal evolution by age 50 years. Secondary somatic mutations in ...

... has been described at the time of myeloid clonal evolution in individuals with different types of syndromes with ... V, Khan SP, Patnaik MM. Clinical spectrum and clonal evolution in germline syndromes with predisposition to myeloid neoplasms. ...

... with prognosis in retrospective and prospective studies and clonal evolution has been seen over time.[ 31 , 41 - 43 ] ... TE, Fink SR, et al.: Prospective evaluation of clonal evolution during long-term follow-up of patients with ...

... or more in one or more precursor lineages. Clonal evolution can eventually lead to the development of acute ... SS, Pastor VB, Goodings C, et al.: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes. Nat Med 27 ( ...

... A, et al.: Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma. Blood ...

... A, et al.: Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma. Blood ...

... MJ, Kurilik G, et al.: The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated ...

... al 2020 ]. Prior to the onset of hematopoietic clonal evolution, individuals may present with bone marrow hypoplasia and ...

... Lundberg P, Karow A, Nienhold R, et al.: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative ...