... an increase in the transcription of the tPA gene.[ 40 ] This transcriptional activation is associated with activation of c-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-kappa B) signaling pathways to ...

... of disease-associated genetic variants in the complement factor H gene. Kidney Int. ... activation in drusen biogenesis. Eye (Lond). 2001; 15 :390– ...

... been reported. These patterns are correlated with clinical factors such as age and appear to be associated with prognosis.[ 3 , 4 ] Figure 1. Schematic diagram showing ligand-stimulated Ras activation, the Ras-Erk pathway, and the gene mutations found to date contributing to the neuro- ...

... T]) showed a JAK2 V617F mutation causing constitutive activation of the JAK2 ... receptor gene rearrangements are candidates for imatinib mesylate at standard ...

... further validating the major role of genetic susceptibility. Genes putatively associated with the risk loci ... comprehensive whole genome sequencing effort was ...

... constitutive AMPK activation in FLCN -null cells. AMPK activation has been shown ... mutations in Birt-Hogg-Dubé-associated renal tumors. J Natl Cancer Inst 97 (12): ...

... Verbruggen L, Van Hul W. Mutations in the gene encoding the latency-associated peptide of ... by altering either activation or secretion of the mutant protein. J Biol ...