- ... in situ hybridization (FISH) . FISH of the BCR :: ABL translocation can be performed using the bone marrow aspirate ... count, splenomegaly, thrombocytosis, and identification of the BCR :: ABL translocation.[ 1 ] Table 1. Treatment Options for CML Phases ...
- ... Chronic myeloid leukemia (CML) results from the BCR :: ABL translocation. CML is primarily an adult disease but represents ...
- ... absence of the Philadelphia chromosome or the BCR :: ABL translocation. Identification of a JAK2 , MPL , or CALR variant ( ...
- ... variants associated with a subset of medulloblastoma cases. ABL family genes activated by translocation in a subset of acute lymphoblastic leukemia (ALL) ...
- ... have been noted to have a series of translocations involving tyrosine-kinase encoding ABL-class fusion genes, including ABL1 , ABL2 , CSF1R , and ...
- ... mutations or variants . Other names: BCR-ABL , BCR-ABL fusion, Philadelphia chromosome, B-cell acute lymphoblastic leukemia (B-ALL), chronic myelogenous leukemia (CML), t(9;22), BCR-ABL1 Transcript Detection by RT-PCR, Quantitative BCR-ABL1 Translocation Detection by RT-PCR What is it used ...
- ... Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996 ... Chromosome Translocations on the Clinical Course of Chronic Myeloid Leukemia. ...
- ... growth of cells. Abelson tyrosine-protein kinase 1 ABL bcr/abl bcr/c-abl oncogene protein c- ...
- ... Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science. 1990 Mar 2;247(4946): ...
- ... 11 ] Chromosomal abnormalities: Chromosomal ... with leukemia and a BCR :: ABL fusion gene who do not demonstrate the classical ...
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