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Severe hemophilia A
- ... pairs. The most common mutation in people with severe hemophilia A is a rearrangement of genetic material called ... activity of coagulation factor VIII and result in severe hemophilia. Other mutations reduce but do not eliminate the ...
- ... be difficult to control. The variants that cause severe hemophilia almost completely eliminate the activity of coagulation factor ...
- ... the activity of coagulation factor IX result in severe hemophilia. Mutations that reduce but do not eliminate the ... from clotting normally and can lead to recurrent, severe bleeding problems. To avoid these complications, ... component, Christmas disease, hemophilia B) FA9_HUMAN Factor 9 FIX HEMB Plasma ...
- ... families. F11 deficiency Factor 11 deficiency Haemophilia C Hemophilia C Plasma thromboplastin antecedent deficiency PTA deficiency Rosenthal ...
- ... reproductive tract bleeding during pregnancy and childbirth. In severe cases of von Willebrand disease, heavy bleeding occurs ... of affected individuals, and is usually the most severe. Another form of the disorder, acquired von Willebrand ...
- ... injury, surgery, or having a tooth pulled. In severe cases of prothrombin deficiency, heavy bleeding occurs after ... the activity of prothrombin and can lead to severe bleeding episodes. Other F2 gene mutations allow for ...
- ... to their sons (no male-to-male transmission). hemophilia , Fabry disease X-linked Because the inheritance pattern ... copy of the gene usually leads to less severe health problems than those in affected males, or ...