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Results 1 - 10 of 307 for Lack of T cell function
  1. CARD11 gene 
    ... of an abnormally short, nonfunctional CARD11 protein. The lack of CARD11 function diminishes T cells' ability to fight foreign invaders, despite normal numbers ...
    https://medlineplus.gov/genetics/gene/card11 - Genetics
  2. STAT3 gene 
    ... from the other copy of the gene. The lack of STAT3's signaling function disrupts the normal maturation of T cells (specifically a subset known as Th17 cells) and ...
    https://medlineplus.gov/genetics/gene/stat3 - Genetics
  3. Activated PI3K-delta syndrome 
    ... infections and that die earlier than usual. The lack of functioning B cells ... immune system function may contribute to the development of lymphoma in ...
    https://medlineplus.gov/.../condition/activated-pi3k-delta-syndrome - Genetics
  4. DOCK8 immunodeficiency syndrome 
    ... this protein impairs normal immune cell development and function. It is thought that ... syndrome. A lack of DOCK8 protein also impairs B cell maturation ...
    https://medlineplus.gov/.../dock8-immunodeficiency-syndrome - Genetics
  5. PIK3CD gene 
    ... protein. These variants are classified as gain-of-function variants because a ... and likely self-destruct. The lack of T cells and B cells makes it ...
    https://medlineplus.gov/genetics/gene/pik3cd - Genetics
  6. FOXP3 gene 
    ... Levings MK, Roncarolo MG. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest. ... X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. 2007 Oct;120(4): ...
    https://medlineplus.gov/genetics/gene/foxp3 - Genetics
  7. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome 
    ... Levings MK, Roncarolo MG. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest. ... X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. 2007 Oct;120(4): ...
    https://medlineplus.gov/...ocrinopathy-enteropathy-x-linked-syndrome - Genetics
  8. IL7R gene 
    ... signaling, development of T cells is disrupted. A lack of T cells reduces the immune system's ability to fight ... Yunes JA, Barata JT. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet. 2011 Sep 4; ...
    https://medlineplus.gov/genetics/gene/il7r - Genetics
  9. Purine nucleoside phosphorylase deficiency 
    ... for destruction. The most severely affected individuals, who lack T cells and B cells, have a serious condition called ...
    https://medlineplus.gov/...urine-nucleoside-phosphorylase-deficiency - Genetics
  10. ZAP70-related severe combined immunodeficiency 
    ... T cells. These include cytotoxic T cells (CD8+ T cells), whose functions include destroying cells infected by viruses. The ZAP70 ... in the activation of helper T cells (CD4+ T cells). These cells direct and assist the functions of the immune system by influencing the activities ...
    https://medlineplus.gov/...-related-severe-combined-immunodeficiency - Genetics
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