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Increased cellular sensitivity to UV light
- ... to have red or blond hair, freckles, and light-colored skin that tans poorly. ... that stimulate these cells to make eumelanin. If the receptor is not ...
- ... the condition, which is characterized by an extreme sensitivity to UV rays from sunlight.Studies suggest that the ERCC2 gene variants responsible for trichothiodystrophy reduce the amount of functional TFIIH complex in cells. Without enough of this complex, cells cannot effectively ...
- ... genes reduce the amount of TFIIH complex within cells, which impairs both DNA repair and gene transcription. An inability to repair DNA damage probably underlies the sun sensitivity in affected individuals. Studies suggest that many of ...
- ... IK, Quillen DA, Iannaccone A, Edwards JG. Diagnostic sensitivity and specificity of dark adaptometry for detection of ...