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Lack of spontaneous play
- ... 1A. Affected infants may have severe muscle weakness, lack of muscle tone (hypotonia), little spontaneous movement, and joint deformities (contractures). Weakness of the ...
- ... an abnormal curvature of the spine (scoliosis), and spontaneous bone fractures. Some affected individuals have a smooth tongue that lacks the bumps that house taste buds (fungiform papillae). ...
- ... Progressive intracranial arterial occlusion Progressive intracranial occlusive arteropathy Spontaneous occlusion of the Circle of Willis Genetic Testing ...