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Abnormal cell proliferation
- ... although the extra digits are probably related to abnormal cell proliferation in the developing hands and feet. CCND2 and ...
- ... signaling through these overactive proteins allows survival and proliferation of abnormal cells that should undergo apoptosis, which likely contributes to ...
- ... is involved in determining the specialized functions a cell will have (differentiation).Abnormal proliferation and differentiation of connective tissue cells called fibroblasts ...
- ... Constitutively active ALK receptor tyrosine kinase may induce abnormal proliferation of immature nerve cells and lead to neuroblastoma.Several mutations in the ...
- ... Overactive PI3K-delta signaling can also stimulate the abnormal proliferation of white blood cells, leading to lymphadenopathy and nodular lymphoid hyperplasia in ...
- ... allows cells to grow and divide continuously. Increased cell proliferation leads to abnormal growth of the bones, soft tissues, and blood ...
- ... intermediate filaments leads to inflammation and promotes the abnormal growth and division (proliferation) of epithelial cells, causing the mucosae to thicken and resulting in ...
- ... self-destruction (apoptosis).Like the ABL1 protein, the abnormal protein produced from the fusion gene, called BCR-ABL1, can promote cell proliferation and block apoptosis. However, unlike ABL1, it does ...
- ... is increased. The constitutively active signaling pathways and abnormal gene activity increase the proliferation and survival of cells.When the ETV6-PDGFRB fusion gene variant (also ...
- ... of transcription leads to uncontrolled growth and division (proliferation) and abnormal maturation and survival of cells, causing tumor development.The EWSR1/FLI1 fusion gene ...