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Target cells
- ... cell-killing proteins, onto the membranes of the target cells. The UNC13D protein helps transport these granules to the membrane of the target cell, allowing cytolytic proteins to enter the cell and ...
- ... cell-killing proteins, onto the membranes of the target cells. Perforin helps create a channel through the membrane, ...
- ... Yaworsky PJ, Walsh FS. Myostatin as a therapeutic target for musculoskeletal disease. Cell Mol Life Sci. 2008 Jul;65(14):2119- ...
- ... deficiency prevents the efficient activation of the T cells to target EBV and other infections. Uncontrolled EBV infection increases the likelihood of developing lymphoma. Impaired production of CD4+ T cells resulting from abnormal magnesium transport likely accounts for ...
- ... proteins and helps maintain the normal functions of cells.One of the targets of the VCB-CUL2 complex is a protein ... of the VHL protein, particularly its ability to target HIF-2α to be broken down. As a result, HIF accumulates in cells even when adequate oxygen is available. The presence ...
- ... mechanism is unclear.In addition, the GRIP1 protein targets necessary proteins to the junctions (synapses) between nerve cells (neurons) in the brain where cell-to-cell ...
- ... s ability to interact with HIF-2α and target it for destruction. Consequently, HIF accumulates in cells even when adequate oxygen is available. The presence ...
- ... Sundaresan P, Veitia RA. The mutations and potential targets of the forkhead transcription factor FOXL2. Mol Cell Endocrinol. 2008 Jan 30;282(1-2):2- ...
- ... and tissues. Attachment of mannose-binding lectin also targets the pathogen to be engulfed and broken down by special immune cells. Recognition of foreign invaders by mannose-binding lectin ...
- ... E3 ubiquitin-protein ligase. Proteins with this activity target other proteins to be broken down (degraded) within cells. Protein degradation is a normal process that removes ...