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Results 1 - 10 of 170 for Lack of T cell function
  1. CARD11 gene 
    ... of an abnormally short, nonfunctional CARD11 protein. The lack of CARD11 function diminishes T cells' ability to fight foreign invaders, despite normal numbers ...
    https://medlineplus.gov/genetics/gene/card11 - Genetics
  2. STAT3 gene 
    ... from the other copy of the gene. The lack of STAT3's signaling function disrupts the normal maturation of T cells (specifically a subset known as Th17 cells) and ...
    https://medlineplus.gov/genetics/gene/stat3 - Genetics
  3. PIK3CD gene 
    ... protein. These variants are classified as gain-of-function variants because a ... and likely self-destruct. The lack of T cells and B cells makes it ...
    https://medlineplus.gov/genetics/gene/pik3cd - Genetics
  4. FOXP3 gene 
    ... Levings MK, Roncarolo MG. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest. ... X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. 2007 Oct;120(4): ...
    https://medlineplus.gov/genetics/gene/foxp3 - Genetics
  5. IL7R gene 
    ... signaling, development of T cells is disrupted. A lack of T cells reduces the immune system's ability to fight ... Yunes JA, Barata JT. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet. 2011 Sep 4; ...
    https://medlineplus.gov/genetics/gene/il7r - Genetics
  6. CTSD gene 
    ... K, Scifo E, Tyynela J, Jalanko A, Braulke T. Cell biology and function of neuronal ceroid lipofuscinosis-related proteins. Biochim Biophys ...
    https://medlineplus.gov/genetics/gene/ctsd - Genetics
  7. CLN5 gene 
    ... K, Scifo E, Tyynela J, Jalanko A, Braulke T. Cell biology and function of neuronal ceroid lipofuscinosis-related proteins. Biochim Biophys ...
    https://medlineplus.gov/genetics/gene/cln5 - Genetics
  8. DOCK8 gene 
    ... DOCK8 protein impairs normal immune cell development and function. It is thought that T cells lacking DOCK8 protein cannot maintain their shape as ... reduced numbers of these cells. A shortage of T cells impairs the immune response to ... syndrome. A lack of DOCK8 protein also impairs B cell maturation ...
    https://medlineplus.gov/genetics/gene/dock8 - Genetics
  9. SPINK5 gene 
    ... is unable to control serine peptidase activity. The lack of LEKT1 function allows the serine peptidases to be abnormally active ... people with Netherton syndrome likely arises from a lack of LEKT1 control of ... system function. Excessive activation of the immune system caused by ...
    https://medlineplus.gov/genetics/gene/spink5 - Genetics
  10. LIPH gene 
    ... leading to fragile hair that breaks easily. A lack of lipase H function in the epidermis likely contributes to the skin ...
    https://medlineplus.gov/genetics/gene/liph - Genetics
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