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Family history of cancer
- ... cases, the cancers occur in people with no family history of the cancer and are considered sporadic. Affected individuals do not ...
- ... somatic) PTEN gene mutations occur in some breast cancers in women without a family history of the disease. Somatic mutations are not inherited and do not occur as part of a familial cancer syndrome. They are acquired during a person's ...
- ... gene mutations also occur commonly in lobular breast cancers in women without a family history of the disease. These genetic changes, known as ... why CDH1 gene mutations increase the risk of cancer in certain tissues and not in ... and with or without a family history of HDGC (both described above). The CDH1 gene ...
- ... Easton DF. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J ...
- ... patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. Dis Colon Rectum. 2005 Jun;48(6):1275-81. doi: 10.1007/s10350-004-0949-5. Citation on PubMed Ceol CJ, Pellman D, Zon LI. APC and colon cancer: two hits for one. Nat Med. 2007 Nov; ...
- ... as muscle, and an aggressive form of skin cancer called melanoma.Non-germinal retinoblastoma occurs in people with no history of the disorder in their family. Affected individuals are born with two normal copies ...
- ... inherited KIF1B gene mutations have been identified in families with a history of neuroblastoma. These mutations change single protein building blocks (amino acids) in the kinesin family member 1B protein. Studies suggest that deletion or ...
- ... abnormalities. Sporadic acromegaly occurs in people with no history of overgrowth in their family. This variant leads to production of an altered ...
- ... the condition that occur in people with no history of these tumors in their families. Most of the SDHB gene mutations involved in ...
- ... the condition that occur in people with no history of these tumors in their families. Most of these mutations change single amino acids ...