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Death in childhood
- ... disease leads to severe signs and symptoms and death in childhood.In the later-onset cases of CLN1 disease, ... those who have the condition beginning in early childhood. As a result, ... and cause nerve cell death, the signs and symptoms of CLN1 disease in ...
- ... the chest muscles that control breathing often causes death from respiratory failure in early childhood.UBA1 gene variants that cause X-linked infantile ...
- ... called mitochondrial DNA (mtDNA), and in controlled cell death (apoptosis). At least 240 mutations in the OPA1 gene have been found to cause optic atrophy type 1. This condition typically results in vision loss beginning in childhood that worsens over time. Affected individuals may also ...
- ... cell damage leading to cell death. The progressive death of nerve cells in the brain and other tissues leads to the signs and symptoms of CLN2 disease.Individuals who are diagnosed with CLN2 disease later in childhood likely have TPP1 gene mutations that result in ...
- ... that impaired oxidative phosphorylation can lead to cell death because of decreased energy available in the cell. ... especially sensitive to decreases in cellular energy. Cell death in the brain likely causes the characteristic changes ...
- ... have mild brain abnormalities resulting from nerve cell death in the brain, but the cause of this cell death is unknown.Some CLN8 gene mutations that cause ...
- ... accumulations can cause cell damage leading to cell death. The progressive death of nerve cells in the brain and other ... begin. The early-onset form begins in late childhood or adolescence, and the late-onset form begins ...
- ... accumulations can cause cell damage leading to cell death. The progressive death of nerve cells in the brain and other ...
- ... motor neurons, leading to cell damage and cell death. The loss of motor neurons causes muscle weakness ... aggregates damage cells and eventually lead to cell death, causing the severe neurological problems seen in children ...
- ... structure of the mitochondria and in controlled cell death (apoptosis). At least four mutations in the OPA3 ... mitochondria and reduced energy production result in the death of these cell types more readily than other ...
