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Results 1 - 10 of 20 for Abnormal platelet function
  1. ... protein, it is described as a "gain-of-function" mutation. Researchers suggest that the abnormal ion flow in platelets causes the cells to break down earlier than ...
  2. ... that cannot carry out their normal infection-fighting functions. These abnormal cells can build up in the blood and bone marrow, leaving less room for healthy white blood cells, red blood cells, and platelets. Children affected by this disorder may experience fatigue, ...
  3. ... abnormally small version of the enzyme that cannot function properly. These ... and may induce platelets to stick together, even in the absence of ...
  4. ... and fewer in number than usual (macrothrombocytopenia). The abnormal platelets also appear gray when viewed under a microscope, ... lack of alpha-granules impairs the clumping of platelets in response to injury, increasing the risk of abnormal bleeding. Myelofibrosis is thought to occur because the ...
  5. ... cause Wiskott-Aldrich syndrome, a condition characterized by abnormal immune system function (immune deficiency) and a reduced ability to form ... these signaling problems primarily affect the development of platelets. In some ... When WASP function is impaired in white blood cells, these cells ...
  6. ... abnormal lysosome-like structures inside blood cells called platelets underlie the abnormal bruising and bleeding seen in people with Chediak- ...
  7. ... in essential thrombocythemia, leads to the overproduction of abnormal megakaryocytes and an increased number of platelets. Excess platelets can cause thrombosis, which leads to ...
  8. ... division (proliferation) of immature red blood cells and platelet-precursor cells (megakaryocytes) to facilitate their specialization (differentiation). To function properly, these immature cells must differentiate into specific ...
  9. ... When variants in the GNE gene reduce the function of the enzyme produced by the GNE gene, platelets have less sialic acid. This lack of sialic ...
  10. ... cells, which protect the body from infections; and platelets, which are involved in blood clotting. As the abnormal hematopoietic stem cells multiply, populations of abnormal blood ...
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