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Abnormal lymphocyte proliferation
- ... of PI3K-delta signaling can also stimulate the abnormal proliferation of lymphocytes, and accumulation of these cells can lead to ...
- ... not inherited and are found only in the abnormal lymphocytes. (Such mutations are known as somatic mutations.) The mutations involved in LGL are classified as "gain-of-function," leading to an overactive ... acute-phase ...
- ... NF-κB signaling. Overactive NF-κB promotes the proliferation of B cells, which can lead to B-cell lymphoma. These abnormal cells, however, cannot respond to infections. T cells ...