- NLM Digital Collections - Disease-modifying therapies for relapsing-remitting and primary-progressive multiple ...Publication: Boston, MA : Institute for Clinical and Economic Review, March 6, 2017... adverse events (e.g., CNS infections, autoimmune diseases, liver toxicity, cancers). In addition, RRMS is a heterogeneous disease, ... Interferon β-1a 30 mcg Depression, suicide, psychosis, liver toxicity, seizures, allergic 4% 14% (Avonex) reactions, CHF, ↓ peripheral ...
- ... given in doses large enough to produce extensive liver toxicity, would produce liver tumors. The further implication is ... basis for protection of public health. Unfortunately, since liver toxicity is not usually examined in carcinogensis tests, information ...
- NLM Digital Collections - Calcitonin gene-related peptide (CGRP) inhibitors as preventive treatments for patients with ....Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, July 3, 2018... the FDA specifically requested postmarketing surveillance data for liver toxicity, myocardial infarction, and stroke among patients receiving erenumab. ...
- NLM Digital Collections - Spinraza and Zolgensma for spinal muscular atrophy : effectiveness and value : final evidence ...Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, May 24, 2019... Return to TOC Zolgensma. In terms of safety, liver toxicity was mitigated by amending the protocol to include ... not been well studied. In terms of safety, liver toxicity was mitigated by amending the protocol to include ...
- ... May 15;124(10):884-90 Methotrexate and liver toxicity: role of surveillance liver biopsy. Conflict between guidelines ... District General Hospital, Sunderland, United Kingdom.): Methotrexate and liver toxicity: role of surveillance liver biopsy. Conflict between guidelines ...
- NLM Digital Collections - Elagolix for treating endometriosis : final evidence reportPublication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, August 3, 2018... to questions related to liver function tests.36 Liver toxicity was not reported in the Phase II and ... to questions related to liver function tests.36 Liver toxicity was not reported in the Phase II and ...
- NLM Digital Collections - Treatment options for hypercholesterolemia : scientific reviewPublication: [Oakland, Calif.] : California HealthCare Foundation, c2004... and without known cardiovascular marketed statins differ in liver toxicity and disease, an important finding because all-cause ... tatin is more or less likely to cause liver toxicity cholesterol levels by inhibiting triglyceride syn- or myotoxicity. ...
- NLM Digital Collections - Siponimod for the treatment of secondary progressive multiple sclerosis : effectiveness and ...Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, June 20, 2019... death, and includes additional warnings for herpes infections, liver toxicity, hypersensitivity reactions (including anaphylaxis), and immunosuppression and infections. ...
- NLM Digital Collections - Gene therapy for hemophilia B and an update on gene therapy for hemophilia A : effectiveness ....Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, December 22, 2022... with Factor VIII. Although valoctocogene roxaparvovec showed initial liver toxicity and increased rates of adverse events such as ... O O 0O 0 O O 0O O = Liver toxicity Other Outcomes: Factor level (factor activity level) Duration ...
- NLM Digital Collections - Chemical warfare agents and related chemical problems (Parts 1-2)Publication: Washington, D.C. : Office of Scientific Research and Development, National Defense Research Committe, Division 9, 1946... compounds that does not occur with arsenite-treated liver slices,303'- Toxicity. Available data on the toxicity of arsine by ... M, AM) CARBONYLS OF IKON AM) NICKEL bronchitis. Liver and kidney damage was also present. 11.2.2 Toxicology The toxicity of cadmium oxide by inhalation is summarized in ...
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