... was ineffective if the patient's cancer had an activating mutation in KRAS (the most important member of the ... J.G., Haluska, F.G., et al. (2004). Activating mutations in the epidermal growth factor receptor underlying responsiveness ...

... Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the downstream GTPase, KRAS, and mutations in ... Some 15%-30% of lung adenocarci- nomas contain activating mutations in the RAS family member KRAS. These mutations ...

... cell lung cancer with epidermal growth factor receptor activating mutations (January 2012). yy E rlotinib is accepted for ...

... 40% to 60% of all melanomas carry this activating mutation. In a study of 49 patients with melanoma, ...

... the lens is overexpression of these genes and negative dominant mutations using retroviral vectors. We have used the avian ... gener- ate mice with heterozygous and homozygous knockout mutations. ... flanked by the negative selectable marker. HSV tk. Use of these positive ...

... endoge- nous genes. Preliminary results indicate that a negative dominant mutation of c-jun has a positive effect on ...

... testing is generally not warranted. When the bacterial mutation assay is negative, but an in vitro chromosome damage test result ( ...

... cuti-reaction. Of the 12 whose milk was activating, 9 gave a positive tuberculin reaction and 3 a negative reaction. Of the 12 whose milk was non-activating for venom, only one gave a positive cuti- ...

... from epidemiologi cal data on human blaod Tynphacytes. - Negative results were reported in a fruit fly point mutation’ study. D.. Toxicology “The oral LD50 of zineb ...

... the assumption that MAV induces renal tumors by activating cellular genes, Dave Westaway has sought the target for insertion mutation. However, none of the cellular homologues of retroviral ...