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  1. pdfNewMeSHheadingsfor2021singlecolumnaftercutover.pdf 
    https://www.nlm.nih.gov/...adingsfor2021singlecolumnaftercutover.pdf
    ... is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, ... cell surface proteins that bind specifically to VIRAL SPIKE PROTEINS found on a CORONAVIRUS. The attachment of the ...
  2. NLM Digital Collections - Technology assessment. Vaccine development : capabilities and challenges for addressing ... 
    Publication: Washington, DC : United States Government Accountability Office, November 2021
    resource.nlm.nih.gov/9918383084506676
    ... or the use of other cells, such as spike protein antigen was the result of decades of previous ... the SARS and Middle East Respiratory Syndrome (MERS) spike protein antigens and vaccines to address a diverse range ...
  3. NLM Digital Collections - Special assessment of outpatient treatments for COVID-19 : final evidence report and meeting .... 
    Publication: [Boston, Massachusetts] : Institute for Clinical and Economic Review, May 10, 2022
    resource.nlm.nih.gov/9918506283506676
    ... could cause mutations in the SARS-CoV-2 spike protein, a key determinant of host antibody and targeted ... there is no clear evidence that emergence of spike protein amino acid changes in MOVe-OUT was associated ...
  4. NLM Digital Collections - Development of monoclonal antibody products targeting SARS-CoV-2 for emergency use ... 
    Publication: Silver Spring, MD : Center for Drug Evaluation and Research, December 2023
    resource.nlm.nih.gov/9918751183806676
    ... receptor binding domain of the SARS-CoV-2 spike protein. Given this clinical context, FDA will continue to ... for a new mAb targeting SARS-CoV-2 spike protein should use the predominant circulating variant at that ...
  5. NLM Digital Collections - FDA oversight 
    Publication: [Toronto, Ontario] : Thomson Reuters, 19-December-2022
    resource.nlm.nih.gov/9918645959006676
    ... apart. The vaccine contains the SARS-CoV-2 spike protein and Matrix-M adjuvant. Adjuvants are incorporated into ... the immune response of the vaccinated individual. The spike protein in this vaccine is produced in insect cells; ...
  6. NLM Digital Collections - Emergency Use Authorization for vaccines to prevent COVID-19 
    Publication: Silver Spring, MD : Center for Biologics Evaluation and Research, May 25, 2021
    resource.nlm.nih.gov/9918350982306676
    ... protective immune response to the SARS-CoV-2 Spike (S) protein, the major structural protein of the virus that ... monoclonal antibodies directed to the SARS-CoV-2 spike protein and is resistant to neutralization by plasma from ...
  7. NLM Digital Collections - Antiviral drugs. Economic incentives and strategies for pandemic preparedness : report to ... 
    Publication: Washington, DC : United States Government Accountability Office, September 2023
    resource.nlm.nih.gov/9918734185306676
    ... name) Fusion Enfuvirtide Fusion inhibitor – Binds to a spike protein on HIV the virus to inhibit viral fusion. ... can be classified into two main specific viral protein as a drug target, and ... potential toxicity. 20 Virus- host (e.g., human) cell processes ...
  8. NLM Digital Collections - FDA oversight 
    Publication: [Toronto, Ontario] : Thomson Reuters, 21-December-2020
    resource.nlm.nih.gov/101777343
    ... monoclonal antibody that is specifically directed against the spike protein of SARS-CoV-2, designed to block the ...
  9. pdf2017MeshTreesWithChangesShown.pdf 
    https://www.nlm.nih.gov/.../2017MeshTreesWithChangesShown.pdf
    ... Membrane Protein 3 Viral Fusion Proteins HIV Envelope Protein gp41 Spike Glycoprotein, Coronavirus Membrane Glycoproteins Antigens, CD9 Antigens, CD47 ...
  10. pdf2018MeShTreeHierarchy.pdf 
    https://www.nlm.nih.gov/mesh/2018/download/2018MeShTreeHierarchy.pdf
    ... gp41 D12.776.964.970.880.910.665...........................................Spike Glycoprotein, Coronavirus D12.776.964.970.880.940...........................................Viral Matrix Proteins D12.776.964.970.910...........................................Viral Tail Proteins ...
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