... onset sarcoidosis Familial granulomatosis, Blau type Familial juvenile systemic granulomatosis Granulomatous inflammatory arthritis, dermatitis, and uveitis, familial Pediatric granulomatous arthritis Blau syndrome National Organization for Rare Disorders (NORD) ClinicalTrials.gov ...

... several essential roles in the immune system's response to foreign invaders, including inflammatory reactions. Studies suggest that most people with Yao syndrome have at least one variation in the NOD2 ...

... cause inappropriate activation of the body's immune response, resulting in inflammatory damage to the brain, skin, and other body systems that lead to the characteristic features of Aicardi-Goutières syndrome. ADAR IFIH1 RNASEH2A RNASEH2B RNASEH2C SAMHD1 TREX1 Aicardi- ...

... anemia), an underactive thyroid gland (hypothyroidism), or chronic ... and divide in response to harmful invaders such as bacteria and viruses. ...

... 2 per million people each year. Stevens-Johnson syndrome (the less severe form of the condition) is more common than toxic epidermal necrolysis.People who are HIV-positive and those with a chronic inflammatory disease called systemic lupus erythematosus are more likely to develop SJS/ ...

... in the signs and symptoms of Aicardi-Goutières syndrome. More About This Health ... disease called systemic lupus erythematosus (SLE). People with TREX1 gene mutations ...

The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and ...

... causes inflammation of blood vessels throughout the body (systemic vasculitis). However, not all researchers classify ADA2 deficiency ... critical role in inflammation. Some macrophages are pro-inflammatory, meaning they promote inflammation, while others are anti- ...