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- Medications for IBS (International Foundation for Gastrointestinal Disorders)... Secretagogues/Prosecretory agents Secretagogues/Prosecretory agents are a class of drugs which increase fluid secretion and movement ... there are 3 FDA approved treatments in this class: lubiprostone, linaclotide, plecanatide, Lubiprostone (Amitiza®) works through the ...