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Leptin receptor deficiency
- Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at ...
- ... At least 18 LEPR gene mutations that cause leptin receptor deficiency have been identified; this disorder is associated with ... extreme weight gain.Because hypogonadotropic hypogonadism occurs in leptin receptor deficiency, researchers suggest that leptin receptor signaling is also ...
- ... the hypothalamus, the binding of leptin to its receptor triggers a series of chemical signals that affect hunger and help produce a feeling of fullness (satiety).LEP gene mutations that cause congenital leptin deficiency lead to an absence of leptin. As a ...
- ... the hypothalamus, the binding of leptin to its receptor triggers a series of chemical signals that affect hunger and help produce a feeling of fullness (satiety). At least seven LEP gene mutations that cause congenital leptin deficiency have been identified. This disorder is associated with ...
